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Anti-TMEFF2-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-437)

This ADC product is comprised of an anti-TMEFF2 monoclonal antibody conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • TMEFF2
  • Alternative Names
  • TMEFF2; transmembrane protein with EGF-like and two follistatin-like domains 2; TR; HPP1; TPEF; TMEFF2; CT120.2; tomoregulin-2; TR-2; tomoregulin; transmembrane protein TMEFF2; hyperplastic polyposis protein 1; cancer/testis antigen family 120, member 2;
  • Target Entrez Gene ID
  • 23671
  • Overview
  • TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer.
  • Overview
  • Anti-TMEFF2 Antibody
  • Species Reactivity
  • Human
  • Name
  • MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-086 Anti-TMEFF2-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
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ADC-W-088 Anti-TMEFF2 (TMEFF2#19)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-087 Anti-TMEFF2-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-089 Anti-TMEFF2 (TMEFF2#19)-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
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ADC-W-455 Anti-MSLN (clone h7D9.v3)-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-466 Anti-MUC16-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-W-465 Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC VC-PAB (valine-citrulline with PAB) MMAE (Monomethyl auristatin E)
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ADC-W-499 Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC mc-VC-PABC MMAE (Monomethyl auristatin E)
ADC-W-462 Anti-GPNMB-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)

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