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Anti-CD19 (MDX1435)-VC-duocarmycin ADC

Anti-CD19 (MDX1435)-VC-duocarmycin ADC (CAT#: ADC-W-595)

Name: Anti-CD19 (MDX1435)-VC-duocarmycin ADC
SKU: ADC-W-595
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-CD19 monoclonal antibody (MDX1435) conjugated via a VC linker to duocarmycin. The duocarmycin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, duocarmycin binds to DNA, causes DNA damage.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Name
CD19

Alternative Names
CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

Target Entrez Gene ID
930

Target UniProt ID
P15391

Overview
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Overview
Human Anti-CD19 Antibody, MDX1435

Generic name
MDX1435

Species Reactivity
Human

Name
VC (valine-citrulline)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
duocarmycin

Description
Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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CAT#	Product Name	Linker	Payload
ADC-W-2519	Anti-CD19 (Denintuzumab)-MC-Vc-PAB-SN38 ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-779	Anti-CD19 (Blinatumomab)-MC-Vc-PAB-MMAE ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE
ADC-W-2518	Anti-CD19 (Denintuzumab)-MC-Vc-PAB-MMAE ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE
ADC-W-775	Anti-CD19 (Taplitumomab paptox)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC	MC-Vc-PAB-DMEA-(PEG2)	duocarmycin SA
ADC-W-778	Anti-CD19 (Blinatumomab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF

CAT#	Product Name	Linker	Payload
ADC-W-536	Anti-EDNRB (endothelin B)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-462	Anti-GPNMB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-475	Anti-CA9-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-494	Anti-SLC39A6-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-471	Anti-CD70-VC-MED-2460-ADC	VC (valine-citrulline)	MED-2460

CAT#	Product Name	Linker	Payload
ADC-W-207	Anti-ER-a36 (clone SNGmBI)-MB-VC-duocarmycin ADC	MB-VC	duocarmycin

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