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Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC (CAT#: ADC-W-2606)

This ADC product is comprised of an anti-ITGB3 Fab' fragment conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • ITGB3
  • Alternative Names
  • ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); GP3A; integrin beta-3; CD61; GPIIIa; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; GT; BDPLT2;
  • Target Entrez Gene ID
  • 3690
  • Overview
  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
  • Overview
  • Humanized Anti-ITGB3 IgG1-Fab’ fragment, Tadocizumab
  • Generic name
  • Tadocizumab
  • Host animal
  • Mouse
  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Other Products

Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-2604 Anti-ITGB3 (Tadocizumab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-444 Anti-ITGB3 (Tadocizumab)-RGD-MMAE-HAS ADC RGD MMAE (Monomethyl auristatin E)
ADC-W-2609 Anti-ITGB3 (Tadocizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-2607 Anti-ITGB3 (Tadocizumab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-2605 Anti-ITGB3 (Tadocizumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-2600 Anti-GPNMB (Glembatumumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-537 Anti-TPBG-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-2612 Anti-MS4A1 (Rituximab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-114 Anti-CD33 (clone m2H12)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-493 Anti-CD19 (clone huB4)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-W-2550 Anti-CD74-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2539 Anti-CD33 (Gemtuzumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2591 Anti-EGFR (Cetuximab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2579 Anti-CEACAM5-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2561 Anti-MSLN (Anetumab )-MC-MMAF ADC MC (maleimidocaproyl) MMAF

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