Premade Antibody Library based Antibody Discovery Service for CAR-T Therapy

Creative Biolabs offers premade antibody library screening service for both reagent and therapeutic antibody discovery. With more than ten years phage display experience, we guarantee to help your antibody reach development milestones faster and effectively. For recent years, our scientists are devoted to developing high affinity antibody to promote the development of immunotherapy programs, which including but not limited to chimeric antigen receptor T (CAR-T) cells therapy.

CAR-T Therapy

During the past years, CAR-T therapy has been considered as a promising and potential therapy approach in hematological malignancies. CARs are genetically engineered fusion proteins composed of an antibody derived extracellular single-chain variable fragment (scFv) with an antigen recognition moiety and an intracellular T-cell activation domain. T-cells with CAR expression can bind to the specific antigen and kill the tumor cells in an HLA-independent manner. Several clinic trials have demonstrated that CAR-T-cell-based adoptive immunotherapy produces a long-term remission in hematological malignancies that exceeds current standard combination therapies. In addition, use of CAR T cells as a treatment for cancer has been most extensively investigated in patients with B cell malignancies, and early results have been encouraging.

Antibody Discovery for CAR-T Therapy from Premade Phage Displayed Antibody Library Fig.1 Overview of chimeric receptor (CAR) T-cell therapy. (Sur, 2020) ^{1, 2}

Premade Phage Displayed Antibody Library Screening for CAR-T Therapy

As the most critical initial step, the generation of specific scFv lay down the most basic foundation of an effective and specific CAR-T therapy. Generally, individual scFvs targeting a surface molecule are either derived from murine or humanized antibodies or synthesized and screened via phage display libraries. During the past decades, Creative Biolabs has integrated a comprehensive portfolio of premade phage display libraries with large capacity for numerous formats antibody production. Our professional scientists are confident in screening novel scFv against the specific antigen provided by our customers or prepared by us. In addition, we also provide customized molecular characterization and downstream optimization service during scFv generation. Our premade phage displayed antibody libraries include:

Libraries	Library ID	Display Technology	Library Format	Species	Library Size
Phage display human scFv libraries	HuScL-2	Phage Display	scFv	Human	1.42×10⁹
	HuScL-4	Phage Display	scFv	Human	2.0×10⁹
	HuScL-6	Phage Display	scFv	Human	1.0×10¹¹
	HuScL-7	Phage Display	scFv	Human	1.1×10¹⁰
Phage display human Fab libraries	HuFabL-4	Phage Display	Fab	Human	1.9×10¹⁰
	HuFabL-5	Phage Display	Fab	Human	1.1×10¹⁰
	HuFabssL-1	Phage Display	Fab	Human	1.8×10¹⁰

Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:

Advantages of Our Service

Numerous phage display antibody libraries with large capacity and diversity
Short study duration without the convert from full monoclonal antibody into scFv
One-stop antibody production and downstream optimization
Professional data interpretation with best after-sale service

With professional service and advanced phage display technology platforms at Creative Biolabs, we offer the best premade antibody library screening service to greatly accelerate your research progress with much lower unpredictable risk. For more detailed information about how we can aid your project, please feel free to contact us.

References

Sur, D., et al. Chimeric Antigen Receptor T-Cell Therapy for Colorectal Cancer. Journal of Clinical Medicine. 2020, 9(1), p.182.
under Open Access license CC BY 4.0, without modification.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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