BCL2L1 Membrane Protein Introduction

Introduction of BCL2L1

Bcl-2-like protein 1 (BCL2L1), encoded by the BCL2L1 gene, belongs to the BCL-2 protein family. BCL-2 family members form heterozygous or homologous dimers and participate in various cell activities as anti-apoptotic or pro-apoptotic regulators. BCL2L1 is expressed at the outer mitochondrial membrane, involved the regulation of mitochondrial membrane potential, controlling the production of reactive oxygen species and release of cytochrome C by mitochondria.

Basic Information of BCL2L1
Protein Name	Bcl-2-like protein 1
Gene Name	BCL2L1
Aliases	Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L, BCLX
Organism	Homo sapiens (Human)
UniProt ID	Q07817
Transmembrane Times	0
Length (aa)	233
Sequence	MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

Function of BCL2L1 Membrane Protein

BCL2-family proteins have been revealed to regulate programmed cell death or apoptosis. Some members of the family (e.g. Bcl-2, Bcl-XL, and Mcl-1) display antiapoptotic functions, while others (e.g. Bax, Bak, and Bok ) exhibit proapoptotic effects. Located at the outer mitochondrial membrane, BCL2L1 controls the generation of reactive oxygen species and release of cytochrome C, which is associated with cell apoptosis. It has been reported BCL2L1 inhibits cell death and seems to regulate cell death through blocking the voltage-dependent anion channel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Besides, BCL2L1 also functions as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

BCL2L1 Membrane Protein Introduction Fig.1 Bcl-2-like protein 1 structure.

Application of BCL2L1 Membrane Protein in Literature

Sun W.C. and Pei L. Rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes. J Neurochem. 2016, 138(2): 233-242. PubMed ID: 27121046

Rno-miR-665 can affect isophenols by counteracting the negative localization of apoptotic BCL2L1, so it can be a potential target for children's anesthesia.
Lin B.C., et al. MicroRNA-184 modulates doxorubicin resistance in osteosarcoma cells by targeting BCL2L1. Psychiatry Investig. 2016, 22: 1761-1765. PubMed ID: 27222034

This study suggested the poor response to drug therapy by targeting BCL2L1 may be associated with up-regulated miR-184 in osteosarcoma patients.
Park H., et al. Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2015, 112(40): 12492-12497. PubMed ID: 26401016

Authors in this study indicated that BCL2L1 and DLC1 may be regarded as potential druggable targets for specific subsets of gastric cancer cases.
Wu H., et al. The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy. 2014, 10(10): 1712-1725. PubMed ID: 25126723

The investigation implicated that the BCL2L1-PGAM5-FUNDC1 axis is involved in receptor-mediated mitophagy in response to hypoxia.
Sillars-Hardebol A.H., et al. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. J Pathol. 2012, 226(3): 442-450. PubMed ID: 22009326

The study indicated that BCL2L1 is not likely to be a driver of chromosome 20q gain associated adenoma-to-carcinoma progression.

BCL2L1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-BCL2L1 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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