BSG Membrane Protein Introduction

Introduction of BSG

Basigin (BSG), also known as extracellular matrix metalloproteinase inducer (of EMMPRIN) or cluster of differentiation 147 (CD147), is a human protein encoded by the BSG gene. This protein is a determining factor in the Ok blood group system. BSG has been shown to be an essential receptor for the red blood cells of the human malaria parasite Plasmodium falciparum.

Basic Information of BSG
Protein Name	Basigin
Gene Name	BSG
Aliases	5F7, EMMPRIN, TCSF, CD147
Organism	Homo sapiens (Human)
UniProt ID	P35613
Transmembrane Times	3
Length (aa)	385
Sequence	MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS

Function of BSG Membrane Protein

BSG is a member of the immunoglobulin superfamily and has structures associated with the putative original form of the family. As a member of the immunoglobulin superfamily involved in a variety of immune phenomena, it is considered that BSG also plays a role in cell recognition. In addition to its ability to induce metalloproteinase, BSG also regulates several different functions, e.g. spermatogenesis, and the expression of lymphocyte reaction monocarboxylic acid transporter. BSG has a number of type I integral membrane receptor ligands, comprising cyclophilin protein Cyp-A and CyP-B, as well as certain integrins.

Fig.1 Structure of BSG membrane protein.

Application of BSG Membrane Protein in Literature

Miyauchi T., et al. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J Biochem. 1991, 110(5): 770-4. PubMed ID: 783610

This article reports that BSG belongs to the immunoglobulin superfamily and may be related to the primordial form of the superfamily.
Ochrietor J.D., et al. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest Ophthalmol Vis Sci. 2003, 44(9): 4084-96. PubMed ID: 12939332

This article reveals the specific and limited expression of 5A11/Basigin-2 explicitly within photoreceptor cells implies that this glycoprotein plays a fundamental role within the retina.
Muramatsu T., et al. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol Histopathol. 2003, 18(3): 981-7. PubMed ID: 12792908

This article suggests that BSG in tumor cells triggers the production or release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, thereby contributing to tumor invasion.
Pushkarsky T., et al. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. J Biol Chem. 2005, 280(30), 27866-71. PubMed ID: 15946952

This article suggests the involvement of a cyclophilin in the regulation of intracellular transport of CD147.

BSG Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-BSG antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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