BVES Membrane Protein Introduction

Introduction of BVES

Blood vessel epicardial substance (BVES), also known as protein 1 (POPDC1), is encoded by the humans BVES gene. BVES is a highly conserved transmembrane protein involved in cell adhesion, cell movement, and has recently been shown to play a role in vesicle transport. It present in various organisms (from flies to humans), and is a member of the evolutionarily conserved protein family Popdc.

Basic Information of BVES
Protein Name	Blood vessel epicardial substance
Gene Name	BVES
Aliases	HPOP1, POPDC1, LGMD2X
Organism	Homo sapiens (Human)
UniProt ID	Q8NE79
Transmembrane Times	3
Length (aa)	360
Sequence	MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP

Function of BVES Membrane Protein

BVES acts as a cell adhesion molecule involved in the establishment and/or maintenance of cellular integrity. It is involved in the formation and regulation of a tight junction (TJ) paracellular permeability barrier in epithelial cells. Through its interaction with VAMP3, BVES plays a role in VAMP3-mediated vesicle trafficking and recycling of different receptor molecules. Besides, BVES is also a caveolae-associated protein, which is important for protecting the cavernous structure and functional integrity of the cell membrane and protecting the heart from ischemic damage.

Fig .1 Structure of BVES membrane protein.

Application of BVES Membrane Protein in Literature

Reese D.E., et al. Cloning and expression of hbves, a novel and highly conserved mRNA expressed in the developing and adult heart and skeletal muscle in the huma. Mamm Genome. 1999,10(9): 913-5. PubMed ID: 10441744

This article reports that BVES is highly conserved among all three species at the amino acid level with 75% identity and 92% similarity.
Osler M.E., et al. Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci. 2005, 118(Pt20): 4667-78. PubMed ID: 16188940

This article reveals a function for BVES in epithelia and supports the hypothesis that BVES contributes to the establishment and/or maintenance of epithelial cell integrity.
Kim M., et al. Frequent silencing of popeye domain-containing genes, BVES and POPDC3, is associated with promoter hypermethylation in gastric cancer. Carcinogenesis. 2010, 31(9): 1685-93. PubMed ID: 20627872

Authors in this group knocked down POPDC3 expression with short hairpin RNAs and examined the consequences on cell migration and invasion. Knockdown of POPDC3 in SNU-216 cells caused increased cell migration and invasion.
Gingold-Belfer R., et al. Popeye domain-containing 1 is down-regulated in failing human hearts. Int J Mol Med. 2011, 27(1): 25-31. PubMed ID: 21069264

This article concluded that POPDC gene expression is modified in end-stage heart failure in humans in a manner suggesting regulatory and/or functional differences between the three family members.
Williams C.S., et al. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest. 2011, 121(10): 4056-69. PubMed ID: 21911938

This article evaluates BVES prevents EMT, and its epigenetic silencing may be an important step in promoting EMT programs during colon carcinogenesis.

BVES Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-BVES antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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