ActivatorPep™ Dengue Virus Type 2 Glycoprotein M, human (CA-LX115)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Product Name
ActivatorPep™ Dengue Virus Type 2 Glycoprotein M, human

Cat. No.
CA-LX115

Product Summary
Creative Biolabs provides an extensive cell activation reagents including Expansion Kits and Activator peptides for global custom, which are suitable to many applications, such as in vitro stimulation antigen-specific cells. Dengue Virus Type 2 Glycoprotein M is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the sequence of the Dengue Virus Type 2 Glycoprotein M. The sequence is derived from UniProt Acc. no. P14340 (POLG_DEN2N) and covers aa 115-284 of the genome polyprotein. Which can be used for in vitro stimulation of Dengue-specific T cells.

Background Information
The Dengue virus can be found in tropical and subtropical areas worldwide and belongs to the family of flaviviruses. Dengue fever is a mosquito transmitted viral infection and can be caused by four distinct serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), inducing high fever, severe muscle pain, and nausea. Dengue virus type 2 (DENV-2) is the most common infecting serotype. Recovery from infection by one Dengue virus induces immunity against the homologous serotype but not against the other three serotypes. Secondary infection with a different DENV serotype can cause the potentially life-threatening dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS).

Applications
Stimulation Reagents

Cross-reactivity
No significant cross-reactivity was observed among analytes in this panel.

Species Reactivity
Human

Purity or Quality Grade
Research Grade

Downstream Application
Pulsing of antigen-presenting cells for research;
Detection and analysis of antigen-specific CD4+ and CD8+ effector/memory T cells in PBMCs;

Product Size
for stimulation of 1×108 cells

Shipping Condition
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Conditions
Store at -20°C.

Shelf life
> 6 Months from date of receipt under proper storage condition.

Product Use Statement
For research use only, not for diagnostic or therapeutic use.

Product Features
Efficient expansion and increased survival rate of Ag-specific T cells;
Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells;

Principle of the Assay
In vitro stimulation of antigen-specific T cells with Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.

Research Category
Immunology

Panel Type
Stimulation for CD4+ and CD8+ T cells

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

ActivatorPep™ Dengue Virus Type 2 Glycoprotein M, human (CA-LX115)

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