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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Natural Killer (NK) cells have emerged as pivotal components of cancer immunotherapy due to their innate ability to identify and eliminate malignant cells without prior sensitization. Recent advancements in genetic engineering have allowed for the development of allogeneic NK cell therapies, which overcome many limitations associated with autologous approaches. Creative Biolabs is at the forefront of these cutting-edge technologies, leveraging a wealth of experience in the field to deliver comprehensive allogeneic engineering NK cell development services.
Creative Biolabs provides the one-stop allogeneic engineering NK cell development service that maximizes the cytotoxic potential, metabolic health, and persistence of engineered NK cells. The service is designed to create potential off-the-shelf NK cell therapies with wide applicability across various targets and cancer types. Our service integrates innovative gene-editing techniques and adjunctive therapies to enhance NK cell functionality.
Fig.1 NK cells engineering strategies.1
The platform employs sophisticated gene-editing techniques to optimize NK cell functionality. Notable strategies include the knockout of the CISH gene to improve metabolic fitness, proliferation, and in vivo persistence. Meanwhile, inhibitory receptors such as PD-1, TIGIT, and CTLA-4 are targeted for KO to overcome exhaustion and immune invasion within the tumor microenvironment (TME).
Creative Biolabs has engineered a membrane-bound TNF-related apoptosis-inducing ligand variant (TRAILv) with high affinity, which targets death receptors DR4 or DR5 in tumor cells. This strategy leverages the natural cytotoxic abilities of NK cells, adding an extrinsic pathway driver to enhance the overall anti-tumor efficacy.
NK cell therapies often face challenges related to poor infiltration into tumors. By overexpressing or engineering chemokine receptors such as CXCR2 and CXCR4, Creative Biolabs enhances NK cell migration and homing to tumor sites, thereby improving therapeutic outcomes.
The expression of high-affinity CD16 receptors on NK cells significantly boosts their ADCC potential. This enables NK cells to more effectively mediate the destruction of tumor cells in the presence of monoclonal antibodies, enhancing overall therapeutic efficacy.
Creative Biolabs' comprehensive workflow ensures high-quality engineered NK cell development, tailored to meet specific therapeutic requirements.
The efficacy of allogeneic-engineered NK cells has been validated in several preclinical researches. For instance, CISH KO NK cells show improved metabolic fitness and prolonged in vivo persistence, leading to enhanced anti-tumor activity.
Fig.2 Deletion of CISH in mature NK cells enhances immunity to primary tumors.2
Q1: How does Creative Biolabs ensure the quality and safety of engineered NK cells?
A1: Creative Biolabs employs stringent quality control measures, including phenotypic and functional assays, to ensure the purity, stability, and efficacy of engineered NK cells. Each batch undergoes rigorous testing before being deemed suitable for therapeutic use.
Q2: What are the main challenges in NK cell engineering?
A2: The primary challenges include ensuring sufficient infiltration into tumor sites and overcoming the immunosuppressive TME. Creative Biolabs addresses these issues through chemokine receptor engineering and the KO of inhibitory receptor genes, respectively.
Creative Biolabs' allogeneic engineering NK cell development service integrates advanced gene-editing techniques and adjunctive therapies to produce highly effective anti-cancer treatments. With comprehensive service details and robust scientific backing, this platform represents a promising approach to next-generation NK cell therapies.
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