Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Advances in synthetic biology have revolutionized the field of cell and gene therapy by introducing gene circuits-engineered DNA sequences that provide living cells with programmable instructions. These gene circuits serve as a multifaceted toolbox, enabling sense-and-respond functionalities and sophisticated decision-making capabilities within cells. Particularly beneficial in allogeneic cell therapies, gene circuits enhance precision, control, and efficacy which are critical for treating complex diseases.
Creative Biolabs stands at the forefront of synthetic biology with a focus on allogeneic cell therapy. Allogeneic cells offer "off-the-shelf" therapeutic solutions, easily scalable to treat multiple patients without the need for personalized cell retrieval. Our services encompass the development of diverse cell types, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), T-cells, and natural killer cells (NK cells), all equipped with sophisticated gene circuits.
Our gene circuit technologies aim to:
Precisely kill diseased cells while sparing healthy ones.
Target cells with unparalleled specificity.
Control gene expression dynamically, even post-administration.
The application of gene circuit strategies in cell therapy has been reported in a number of scientific studies. For example, researchers summarized the synthetic biology strategy to enhance the safety and controllability of CAR-T cells.
Fig.1 Synthetic biology strategy to enhance the safety and controllability of CAR-T cells.1
Q1: How does Creative Biolabs ensure the safety of its allogeneic gene circuit therapies?
A1: We employ rigorous validation processes, reduce immunogenicity risks with human-derived systems, and meticulously monitor for gene expression leakage.
Q2: What makes Creative Biolabs' services unique?
A2: Our comprehensive, end-to-end service platform from design to industrial scaling, combined with advanced synthetic biology expertise and proprietary technologies.
Q3: How might future advancements in synthetic biology impact cell therapy?
A3: We anticipate that continued advancements will lead to even more sophisticated and universally applicable therapies, enhancing safety and efficacy continually.
Creative Biolabs is committed to harnessing the potential of genetic circuits to develop transformative allogeneic cell therapy solutions. Through dedicated research and industrial expertise, we aim to meet the evolving needs of the biomedical field, ultimately providing safer and more effective solutions for cell therapy research.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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