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Anti-AKAP13 T cell receptor (CB4), pCDTCR1 (TCR-YC0072)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-AKAP13 T cell receptor (TCR) is constructed for the engineering of T cell to target A-kinase anchor protein 13 (KLMNIQQQL) restricted by HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing AKAP13-specific T cell receptor.

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Details

  • Target
  • AKAP13
  • Target Species
  • Human
  • Epitope
  • KLMNIQQQL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A2
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CB4
  • Host Species
  • Human

Target

  • Introduction
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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