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The vector of anti-CD33 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD33. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD33 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute myeloid leukemia (AML).
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CAR Construction :
Fig.1 Degranulation activity (% CD8/CD107a+ cells) of the m2H12 and My9.6 scFvs with the three architectures. |
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CAR Construction :
Fig.2 Degranulation activity (% CD8/CD107a+ cells) of 7 constructions : M195-V1, M195-V3, M195-V5, m2H12-Vl, m2H12-V3 and My9.6-Vl and My9.6-V3. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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