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The vector of anti-LLE chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human LLE. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-LLE antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of cancer.
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CAR Construction : TH69-41BB-CD3ζ
Fig.1 The expression of CD107a. FHVH1-4 and TH69 CAR exhibited different levels of CD107a releasement after being stimulated by target cells. Dai, Z., Mu, W., Zhao, Y., Cheng, J., Lin, H., Ouyang, K., ... & Zhou, J. (2022). T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape. Signal transduction and targeted therapy, 7(1), 1-12. |
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CAR Construction : TH69-41BB-CD3ζ
Fig.2 Cytotoxicity assay in vitro. Luciferase-based cytotoxicity assays of FHVH1-4 and TH69 CAR-T cells against tumor cells after 24 h incubated with target cells at indicated E:T ratios. Dai, Z., Mu, W., Zhao, Y., Cheng, J., Lin, H., Ouyang, K., ... & Zhou, J. (2022). T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape. Signal transduction and targeted therapy, 7(1), 1-12. |
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