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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 CEA (A3B3) h(28OXζ), which is constructed for the engineering of T cells to target human CEA. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-CEA antibody linked to a CD28 transmembrane domain/ endodomain and OX40, CD3-zeta signaling domains. And the vector product was designed for the treatment of Pancreatic cancer.
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CAR Construction :
Fig.2 Reactivity of Ch F11-39-dgRTA with purified CEA in ELISA. All measurements were performed in triplicate. AGUCHI, H. S., & KURokº, M. Anti-tumor Effect of an Immunotoxin Consisting of a Chimeric Anti-carcinoembryonic Antigen Antibody Conjugated to Ricin Toxin A. |
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CAR Construction :
Fig.3 Binding of Ch F11-39-dgRTA to CEA-expressing tumor cells in flow cytometric analysis. All measurements were performed in triplicate. AGUCHI, H. S., & KURokº, M. Anti-tumor Effect of an Immunotoxin Consisting of a Chimeric Anti-carcinoembryonic Antigen Antibody Conjugated to Ricin Toxin A. |
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CAR Construction : F11-35 scFv-28ζ
Fig.1 Competitive inhibition assays of chimeric antibodies 11-35 against parental MAbs for CEA binding in SPEIAs using purified biotinylated CEA. Five ng of biotinylated CEA and increasing amounts of soluble competitor antibodies were simultaneously added to each well. The biotinylated CEA bound to the immobilized antibody were then detected with avidinperoxidase conjugate. ARAKAWA, F., HARUNO, M., KUROKI, M., KANDA, H., WATANABE, T., MISUMI, Y., & MATSUOKA, Y. (1993). Construction and Expression of Two Mouse—Human Chimeric Antibodies with High Specificity and Affinity for Carcinoembryonic Antigen. Hybridoma, 12(4), 365-379. |
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