Close

Anti-glia-α1a T cell receptor (1383P.A.3), pCDTCR1 (TCR-YC0456)

Online Inquiry  Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Celiac disease (CeD) provides an opportunity to study the specificity underlying human Tcell responses to an array of similar epitopes presented by the same human leukocyte antigen-II (HLA-II) molecule. Provided is a TCR which binds the immunodominant HLA-DQ2.5-restricted gluten epitopes, DQ2.5- glia-α1a (PFPQPELPY).

Specific Inquiry

  • Size:
  • Marker:
  • Form:
  Add to Cart

Details

  • Target
  • glia-α1a
  • Target Species
  • Wheat
  • Epitope
  • PFPQPELPY
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DQ2.5
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 1383P.A.3
  • Host Species
  • Human

Target

  • Introduction
  • In HLA-DQ2-associated CD, a series of gluten epitopes have been characterized, including peptides derived from wheat subfractions (α-, β-, γ-, and ω-gliadin and low- and high-moleclular-weight glutenins) and closely related sequences in barley hordeins and rye secalins. The immunodominant wheat gluten peptide comprises two overlapping T-cell determinants (DQ2.5-glia-α1a (PFPQPELPY) and DQ2.5-glia-α2 (PQPELPYPQ)) contained within a single, protease-resistant α-gliadin 11 mer.

Customer Reviews and Q&As

There are currently no customer reviews or questions for Human anti-glia-α1a T cell receptor (1383P.A.3), pCDTCR1 (TCR-YC0456). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry

For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Key Updates
Newsletter NEWSLETTER

The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders

LEARN MORE NEWSLETTER
New Solution NEW SOLUTION

CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.

LEARN MORE SOLUTION
NOVEL SOLUTION NOVEL TECHNOLOGY

Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.

LEARN MORE NOVEL TECHNOLOGY
NEW TECHNOLOGY NEW SOLUTION

Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.

LEARN MORE SOLUTION
Receive our latest news and insights.