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The vector of anti-HMW-MAA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HMW-MAA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-HMW-MAA antibody linked to CD4 transmembrane domain and FcεRIγ signaling domains. And the vector product was designed for the treatment of metastatic melanoma.
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CAR Construction : 225.28S-CD28-CD3ζ
Fig.1 Cytokine IFN-γ release assay. Peripheral blood lymphocytes from two additional donors were transduced with the three reactive CARs and cocultured with CSPG4-positive cell lines from multiple different histologies. Each of the CSPG4 CAR transduced PBL cultures yielded IFN-γ effector cytokine release Beard, R. E., Zheng, Z., Lagisetty, K. H., Burns, W. R., Tran, E., Hewitt, S. M., ... & Morgan, R. A. (2014). Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells. Journal for immunotherapy of cancer, 2(1), 1-11. |
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CAR Construction : 225.28S-CD28-CD3ζ
Fig.2 Specific killing by CSPG4 CAR transduced T cells. CSPG4 CAR-transduced PBL were mixed with the indicated GSC lines at various effector to target ratios and cytolytic function determined. Beard, R. E., Zheng, Z., Lagisetty, K. H., Burns, W. R., Tran, E., Hewitt, S. M., ... & Morgan, R. A. (2014). Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells. Journal for immunotherapy of cancer, 2(1), 1-11. |
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