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Anti-Human CD32A (XW-407)-BBZ CAR IVT mRNA (XS-0822-YF3167)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

In vitro transcription (IVT) is the synthesis of RNA molecules. Creative Biolabs produces CAR mRNAs with our proprietary production platform, ensuring the quality and expression efficiency. This product is anti-CD32A scFv (XW-407)-BBZ chimeric antigen receptor (CAR) mRNA which can be used for CAR expression in various immune cells.

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CAR Information

  • Target Species
  • Human
  • Clone
  • XW-407
  • Host
  • Mouse
  • CAR Construction
  • scFv-41BB-CD3ζ
  • CAR Generation
  • Second
  • CAR Signaling Description
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

CAR mRNA Properties

  • Cap
  • Cap 1
  • PolyA
  • Segmented PolyA
  • Product Type
  • CAR IVT mRNA
  • Concentration
  • Lot specific
  • Buffer
  • 1 mM Sodium citrate (pH 6.4)
  • Storage
  • Aliquot and store at -80°C. Avoid freeze/thaw cycles.
  • Handling
  • Thaw and work with mRNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

mRNA Quality Control

  • OD260/280
  • PASS
  • Agarose Gel Mobility
  • PASS
  • IVT Vector Sequencing
  • PASS
  • IVT Vector Enzyme Digestion
  • PASS
  • mRNA Transfection Efficiency
  • PASS
  • CAR Expression after mRNA Transfection
  • PASS

Target Information

  • Target
  • CD32A
  • Gene Name
  • FCGR2A
  • Full Name
  • Fc gamma receptor IIa
  • Introduction
  • This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
  • Related Diseases
  • Breast cancer
  • Alternative Names
  • CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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