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Anti-Human GRM2 (XW-488)-BBZ CAR, pCARIVT (XS-0822-YF488)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The IVT vector of anti-GRM2 scFv (XW-488)-BBZ chimeric antigen receptor (CAR) is constructed for the CAR mRNA production. The CAR components consist of scFv of anti-GRM2 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. The IVT components consist of T7 promoter-5' UTR-Kozak-CAR-Stop-3' UTR-PolyA.

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Details

  • Target
  • GRM2
  • Targeting Diseases
  • Testis cancer
  • Generation
  • Second
  • Vector Name
  • pCARIVT
  • Vector Type
  • In Vitro Transcription (IVT) Vector
  • Key IVT Component
  • T7 promoter-5' UTR-Kozak-CAR-Stop-3' UTR-PolyA
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • XW-488
  • Host
  • Camel
  • Target Species
  • Human
  • Gene Name
  • Metabotropic glutamate receptor 2
  • Synonyms
  • GRM2; GPRC1B; MGLUR2; mGlu2; glutamate metabotropic receptor 2; mGluR2; GLUR2
  • Introduction
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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