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Anti-hVEGFR-1 (V1) (28OX3ζ) CAR-MA, pAd5f35 Vector (XS-0823-LX93)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Details

  • Target
  • VEGFR-1
  • Cell Type
  • Macrophage
  • Targeting Diseases
  • Lung malignancy
  • Vector Name
  • pAd5f35
  • Vector length
  • ~8 kb
  • Vector Type
  • Adenoviral vectors
  • Size
  • 10 µg
  • Storage
  • Store at -20°C for long term.

CAR Components

  • scFv
  • V1
  • Hinge
  • CD8
  • TM
  • CD28
  • ICD
  • CD28-OX40-CD3ζ
  • Marker
  • GFP or N/A
  • Receptor Construction
  • scFv-hinge(CD8)-TM(CD28)-ICD(CD28-OX40-CD3ζ)
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    OX40
    OX40, also known as CD134 or TNFRSF4 is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation. The interaction between OX40 and its binding partner, OX40L (CD252) plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells and modulate cytokine receptor signaling. OX40 cosignaling in CAR improve redirected T-cell effector functions and enhance anti-tumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ, ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Target
  • VEGFR-1
  • Target Species
  • Human
  • Clone
  • V1
  • Host
  • Humanized
  • Gene Name
  • Soluble vascular endothelial growth factor receptor-1
  • Introduction
  • The VEGFR-1 (Flt-1) gene expresses 2 mRNAs: one is a long form of approximately 8 kb, and the other is a short form of 2.5 to 3.0 kb. The short mRNA is highly expressed in normal placenta, encoding a soluble form of Flt-1 known as sFlt-1.The sFlt-1 contain 6 Ig-like domains with a short, 31 amino acid-long tail derived from the 5' region of intron 13 and exhibits a strong binding ability to VEGF-A, PlGF, and VEGF-B.
  • Alternative Names
  • VEGFR-1; Soluble vascular endothelial growth factor receptor-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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