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The vector of anti-L1 cell adhesion molecule(L1-CAM) chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human L1 cell adhesion molecule(L1-CAM). The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-L1 cell adhesion molecule(L1-CAM) antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of L1-CAM+ ovarian cancer.
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CAR Construction :
Fig.1 Binding of H2 scFv antibodies to L1Fc in the presence of H2-P11, Scr-H2, and E4-P8 peptides at concentrations up to 100 ug/ml. Binding of single-chain variable fragment (scFv) antibodies to L1Fc by peptides derived from the VH-CDR3 region of L1 scFv antibodies or control peptides and effects of these peptides on neurite outgrowth from cerebellar granule neurons. Dong, L., Chen, S., & Schachner, M. (2003). Single chain Fv antibodies against neural cell adhesion molecule L1 trigger L1 functions in cultured neurons. Molecular and Cellular Neuroscience, 22(2), 234-247. |
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