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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 L1CAM (AB417) h(28ζ), which is constructed for the engineering of T cells to target human L1CAM. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-L1CAM antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Ovarian cancer.
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CAR Construction :
Fig.1 Biodistribution study after injection of 64Cu-Ab417 in a Choi-CK xenograft model. Radioactivity in tissues is expressed as the percentage of injected dose per gram of tissue (%ID/g). Cho, S., Lee, T. S., Song, I. H., Kim, A. R., Lee, Y. J., Kim, H., ... & Hong, H. J. (2017). Combination of anti-L1 cell adhesion molecule antibody and gemcitabine or cisplatin improves the therapeutic response of intrahepatic cholangiocarcinoma. PLoS One, 12(2), e0170078. |
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CAR Construction :
Fig.2 Anti-tumor efficacy of combined treatment with Ab417 and gemcitabine or cisplatin in a Choi-CK model. Each point indicates the mean ± s.d (n = 8). Cho, S., Lee, T. S., Song, I. H., Kim, A. R., Lee, Y. J., Kim, H., ... & Hong, H. J. (2017). Combination of anti-L1 cell adhesion molecule antibody and gemcitabine or cisplatin improves the therapeutic response of intrahepatic cholangiocarcinoma. PLoS One, 12(2), e0170078. |
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