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Anti-MAGEA29 T cell receptor (B32G7), pCDTCR1 (TCR-YF039)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-MAGEA29 T cell receptor (TCR) is constructed for the engineering of T cell to target MAGEA29. The T cells are genetically modified through transduction with a lentiviral vector expressing MAGEA29-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.

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Details

  • Target
  • MAGEA29
  • Target Species
  • Human
  • Epitope
  • KVAELVHFL
  • Format
  • Humanized
  • Allele
  • HLA‐A*0201
  • Targeting Diseases
  • Melanoma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • B32G7
  • Host Species
  • Mouse

Target

  • Introduction
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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