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S19-2 binds to HLA-A*2402-Nef138-10. The TCR was derived from cytotoxic T lymphocyte clones isolated from Japanese HIV patients, specific for different HIV epitopes presented by locus-disparate MHCs, HLA-A*2402. The variable domains of the S19-2 TCR consist of Vδ1 (TRDV1) and Vβ30 (TRBV30) segments.The affinity value of the S19-2 TCR for HLA-A*2402-Nef138-10 is about 1.06 μM. Extraordinarily, the S19-2 has extremely low dissociation rates (i.e., long half-lives), at 0.0265 1/s.
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