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The vector of anti-NY-ESO-1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human NY-ESO-1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-NY-ESO-1 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Melanoma.
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CAR Construction : T1 scFv-28ζ
Fig.1 Primary human T cells 5 days after transduction with T1/28z retroviral vector, stained with HLA-A2/NYESO pentamer. Cells are gated on FSC/ SSC only. Chromium release cytotoxicity assay using T1/28z-transduced T cells as effectors against Maus, M. V., Plotkin, J., Jakka, G., Stewart-Jones, G., Rivière, I., Merghoub, T., ... & Sadelain, M. (2016). An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity. Molecular Therapy-Oncolytics, 3, 16023. |
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CAR Construction : T1 scFv-28ζ
Fig.2 Human melanoma lines SK Mel 37, SK Mel 23, or SK Mel 52. GFP, green fluorescent protein. T1/28z CAR construct. Maus, M. V., Plotkin, J., Jakka, G., Stewart-Jones, G., Rivière, I., Merghoub, T., ... & Sadelain, M. (2016). An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity. Molecular Therapy-Oncolytics, 3, 16023. |
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CAR Construction : T1 scFv-28ζ
Fig.3 T1/28z or CAR. MFI shown is mean fluorescence intensity of GFP+ cells. Plots shown are gated only on fsc/ssc. Maus, M. V., Plotkin, J., Jakka, G., Stewart-Jones, G., Rivière, I., Merghoub, T., ... & Sadelain, M. (2016). An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity. Molecular Therapy-Oncolytics, 3, 16023. |
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