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Anti-OR14C36 T cell receptor (IA2), pCDTCR1 (TCR-YC0779)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-OR14C36 T cell receptor (TCR) is constructed for the engineering of T cell to target Olfactory Receptor Family 14 Subfamily C Member 36 variant FML_V6L (FMLYLLTLM) restricted by HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing OR14C36-specific T cell receptor.

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Details

  • Target
  • OR14C36
  • Epitope
  • FMLYLLTLM
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A2
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • IA2
  • Host Species
  • Human

Target

  • Introduction
  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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