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Anti-Peptide EKP T cell receptor ((Ob.1A12)-3), pCDTCR1 (TCR-YC0896)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Peptide EKP T cell receptor (TCR) is constructed for the engineering of T cell to target Peptide EKP (EKPKYEAYKAAAAPA) restricted by HLA-DRB1*15:01. The T cells are genetically modified through transduction with a lentiviral vector expressing Peptide EKP-specific T cell receptor.

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Details

  • Target
  • Peptide EKP
  • Epitope
  • EKPKYEAYKAAAAPA
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DRB1*15:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • Ob.1A12
  • Host Species
  • Human

Target

  • Introduction
  • Multiple sclerosis (MS) is thought to involve CD4 T cell recognition of self myelin, many studies focusing on a pathogenic role for anti-myelin, HLA-DR15-restricted T cells. In experimental allergic encephalomyelitis, it is known which epitopes trigger disease and that disease is associated with determinant spread of T cell reactivity. Characterization of these events in human MS is critical for the development of peptide immunotherapies, but it has been difficult to define the role of determinant spread or define which epitopes might be involved.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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