Close

Anti-pM45 T cell receptor (611), pCDTCR1 (TCR-YC1003)

Online Inquiry  Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The TCR clone recognizes HGIRNASFI in the context of Db class I molecule.

Specific Inquiry

  • Size:
  • Marker:
  • Form:
  Add to Cart

Details

  • Target
  • pM45
  • Target Species
  • MuHV1
  • Epitope
  • HGIRNASFI
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Db
  • Targeting Diseases
  • Herpesvirus infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 611
  • Host Species
  • Mouse

Target

  • Introduction
  • Murine CMV (MCMV) is a natural herpesvirus infection of mice and thus provides a good model to study the effects of immune evasion on the host immune response. This paper investigates the effect of an immune evasion gene that profoundly inhibits presentation of a viral epitope on the immunodominance of that epitope. MCMV encodes three genes, m4, m6, and m152, which interfere with Ag presentation to CD8 T cells. The m4/gp34 protein binds to MHC class I molecules in the endoplasmic reticulum (ER) and on the cell surface. The m6/gp48 protein redirects class I to the lysosome for degradation. Finally, m152 retains class I in the ER cis-Golgi intermediate compartment.

Customer Reviews and Q&As

There are currently no customer reviews or questions for Mouse anti-pM45 T cell receptor (611), pCDTCR1 (TCR-YC1003). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry

For any technical issues or product/service related questions, please leave your information below. Our team will contact you soon.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Key Updates
Newsletter NEWSLETTER

The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders

LEARN MORE NEWSLETTER
New Solution NEW SOLUTION

CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.

LEARN MORE SOLUTION
NOVEL SOLUTION NOVEL TECHNOLOGY

Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.

LEARN MORE NOVEL TECHNOLOGY
NEW TECHNOLOGY NEW SOLUTION

Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.

LEARN MORE SOLUTION
Receive our latest news and insights.