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The vector of anti-PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human PSCA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-PSCA antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Prostate cancer.
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CAR Construction :
Fig.1 Activation of CD4+ and CD8+ T cells dependent upon their cross-linkage with PSCA+ tumor cells via humanized scBsTaFv CD3-PSCA. Unstimulated CD4+ or CD8+ T cells were cocultured with PSCA+ PC3-PSCA tumor cells (PSCA+) without any Ab. Feldmann, A., Arndt, C., Töpfer, K., Stamova, S., Krone, F., Cartellieri, M., ... & Bachmann, M. (2012). Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells. The Journal of Immunology, 189(6), 3249-3259. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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