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pCDCAR1 TFAP4 h(BBζ) (CAR-YJ250)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-TFAP4 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TFAP4. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TFAP4 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of Colorectal cancer.

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Details

  • Target
  • TFAP4
  • Epitope
  • aa 93-193
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Colorectal cancer
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • 7A10
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Transcription Factor AP-4
  • Synonyms
  • TFAP4; Transcription Factor AP-4; Class C Basic Helix-Loop-Helix Protein 41; Activating Enhancer-Binding Protein 4; BHLHc41; Transcription Factor AP-4 (Activating Enhancer-Binding Protein 4); Transcription Factor AP-4 (Activating Enhancer Binding Protein 4); AP-4
  • Introduction
  • TFAP4 is a transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. TFAP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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