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One epitope, amino acids 49-57 of virion protein 22 (VP22), encoded by gene UL49, is immunodominant in terms of cell number and population prevalence when referenced to the current integrated data set. Amongst persons with the restricting HLA B*0702 allele, about 50% have CD8 (+) lymphocytes in peripheral blood at a level high enough to detect with direct staining with tetramers of HLA B*0702 and the peptide (sequence RPRGEVRFL).
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