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The vector of anti-CD19 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD19. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-CD19 antibody linked to CD3ζ and CD28 signaling domains. And the vector product was designed for the treatment of chronic lymphoid leukemia.
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CAR Construction :
Fig.1 Relative binding affinities of clone Denintuzumab/huB4 and huB4-DGN462 on Ramous cells. Hicks, S. W., Tarantelli, C., Wilhem, A., Gaudio, E., Li, M., Arribas, A. J., ... & Bertoni, F. (2019). The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. haematologica, 104(8), 1633. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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