Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
As a recognized service provider, Creative Biolabs'highly skilled team can provide CellRapeutics™ first generation of CARs products to meet your specific needs. Creative Biolabs has built up a unique and unparalleled platform for producing a variety of CARs engineered immune cells, which can greatly help and accelerate your research progress.
Fig.1 First generation scFv vs. receptor ligand-based chimeric antigen receptors (CARs).1
The design of the first generation CARs includes a scFv targeting tumor associated antigen (TAA), a space (hinge), a transmembrane region (TM) and an intracellular signaling domain. Clinical trials have shown that the first generation CAR-engrafted T cells are a very feasible concept in the treatment for some cancer patients. The application of CAR-engineered T cells have more advantages than the traditional T cell immunotherapy, which includes major histocompatibility complex (MHC)-independent antigen recognition in treating viral infection as well as cancer. Recent reports show that the first generation CAR modified T cells with anti-CD19 specificity has entered phrase I clinical trial for B cell malignances.
The scFv of the first generation CAR is derived from a monoclonal antibody specific to TAAs which is presented on tumor cell surface in various malignancies. Our seasoned scientists can provide a broad range of highly customized service for scFvs design to meet the growing requirements from our clients. An intracellular signaling domain is derived from the CD3ζ chain of the T cell receptor (TCR) complex, which can activate T cells. In addition to CD3ζ, FcεRIγ can also be used as an intracellular signaling domain.
Creative Biolabs offers you sophisticated strategy and the best-in-class CellRapeutics™ first generation CARs products, which can meet and exceed your original expectations.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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