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Anti-VP22 T cell receptor (CB-C098), pCDTCR1 (TCR-C358)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-VP22 T cell receptor (TCR) is constructed for the engineering of T cell to target HSV-2 VP22. The T cells are genetically modified through transduction with a lentiviral vector expressing VP22-specific T cell receptor. And the vector product was designed for the treatment of HSV-2 infection.

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Details

  • Target
  • VP22
  • Target Species
  • HSV-2
  • Epitope
  • RPRGEVRFL
  • Format
  • Non-modified TCR
  • Allele
  • HLA-B*07:02
  • Targeting Diseases
  • HSV-2 infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CB-C098
  • Host Species
  • Human

Target

  • Official Symbol
  • VP22
  • Introduction
  • Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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