NHP Model Development Service

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative Biolabs has developed a series of animal disease models for CAR-T preclinical in vivo tests, which can be used for early studies of CAR-T toxicology and safety, PD/PK, and disease pathogenesis. Non-human primates (NHP) models are the only clinically relevant models for evaluating immune-related toxicities and can be used for preclinical evaluation of potentially fatal clinical toxicities, such as cytokine storm. The comprehensive non-GLP NHP platform provided by our professional cell therapy team can be used to evaluate the physiological effects and safety of CAR-T therapy, which can accelerate the clinical transformation of CAR-T products. In addition, our NHP model provides you with fast, cost-effective, and reliable data to guide future GLP work and clinical trials.

Advantages of NHP Models

NHP Models In principle, smaller animal models, such as rodents and rabbits, are more widely used for initial screening of pharmaceutical agents, which can provide a wealth of useful knowledge about drug efficacy, efficacy/pharmacodynamic characteristics, and adverse reactions. However, this preliminary data has limited predictability and accuracy when translated into humans. On the other hand, NHP has a high degree of homology with humans, the immune system is completely intact, and the way the disease progresses is also highly similar to humans. Therefore, NHP disease models can usually produce more accurate and convincing data, and provide more concrete evidence for pathogenesis and preclinical research.

Our NHP Models Construction Capabilities

Key Features

Demonstrate robust multi-lineage engraftment of human immune cell populations, including very good T cell maturation and long-term research functions.
Human CD34 + cells are stably implanted in bone marrow.
The transplantation has been stable for more than one year, and there is no graft-versus-host disease.
CD4 + and CD8 + T cells are present in the circulation and other tissues.
Using hu-IL15, you can test the efficacy of NK cell-mediated therapies (including ADCC).
It is very suitable for testing the therapy of T cell MOA that is not related to antigen.
Most suitable for T cell and myeloid cell-dependent MOA therapies, including therapies for AML.

In Creative Biolabs, we provide various NHP sources (such as rhesus monkeys, cynomolgus monkeys, cynomolgus monkeys, and green monkeys), and our customers can always find the most suitable choice. Our experts are very experienced in designing, executing, and interpreting NHP-related projects, and we also support CAR-T product safety testing in these models. In addition, we also have extensive and healthy dedicated NHPs, advanced research facilities, GLP-compliant laboratories, and an experienced scientific team. A well-trained team of scientists will be assigned to your project, from the initial experimental design to the final data analysis, working closely with you to ensure the most relevant and reliable results. Please feel free to contact us for further discussion.

Comprehensive Applications

NHP can be used to evaluate the immune safety of various CAR-T products, including:

Perform immunological analysis of FACS and common immune cell markers (including cytokines, CD markers, immune checkpoint targets)
Analysis of serum markers
Conduct clinical observations to determine potential adverse reactions related to Cytokine Storm/CRS
Changes in heart rate and/or body temperature
Redness or swelling of the face
Vomiting, diarrhea, tremor, drowsiness, low blood pressure, difficulty breathing

For more detailed information, please feel free to contact us or directly sent us an inquiry.