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pAAV MUC3A (XW-712) h(BBζ) (XS-1122-YF7152)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-MUC3A chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human MUC3A. The T cells are genetically modified through transduction with a adeno-associated virus encoding the CAR component expressing scFv (XW-712) of anti-MUC3A antibody linked to 41BB and CD3ζ signaling domains. The vector product was designed for the discovery and development of cellular therapy against Non-small cell lung cancer.

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Details

  • Target
  • MUC3A
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Non-small cell lung cancer
  • Generation
  • Second Generation
  • Vector Name
  • pAAV
  • Vector Type
  • Adeno-associated viral (AAV) vector
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • XW-712
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • mucin 3A, cell surface associated
  • Synonyms
  • MUC3; MUC-3A
  • Introduction
  • The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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