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pCDCAR1 SLC7A8 h(BBζ) (CAR-YJ1221)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-SLC7A8 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human SLC7A8. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-SLC7A8 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains.

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Details

  • Target
  • SLC7A8
  • Epitope
  • aa 467-536
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Other
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • 3F10
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • SLC7A8
  • Synonyms
  • Solute Carrier Family 7 Member 8; Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 8; LType Amino Acid Transporter 2; LAT2; Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 8; Solute Carrier Family 7 (Amino Acid Transporter, LType), Member 8;
  • Introduction
  • SLC7A8 is sodium-independent, high-affinity transport of small and large neutral amino acids such as serine, alanine, threonine, cysteine, phenylalanine, leucine, tyrosine, arginine and tryptophan, when associated with SLC3A2/4F2hc. SLC7A8 acts as an amino acid exchanger. SLC7A8 has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. SLC7A8 plays a role in basolateral (re)absorption of neutral amino acids. SLC7A8 also has been involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D, L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. SLC7A8 has been involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. SLC7A8 plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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