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The vector of anti-Trop-2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human Trop-2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-Trop-2 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Ovarian cancer, Melanoma.
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CAR Construction :
Fig.1 The evaluation of the anti-tumor activity of a clone K5-107 on xenograft treatment models using PK-59 cells. |
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CAR Construction :
Fig.2 The reactivity of K5-70, K5-107, T5-86 and K5-116-2-1 antibodies with hTROP-2 (upper case), with hmTROP-2-A (middle case) and with hmTROP-2-B (lower case) was studied. An hTROP-2 gene and each human/mouse chimeric TROP-2 gene were introduced into HEK293 cells, and FACS analysis was then carried out using the cells, in which the genes were transiently expressed. |
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