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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 CD20 (Obinutuzumab) h(BBζ), which is constructed for the engineering of T cells to target human CD20. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-CD20 antibody linked to 4-1BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute lymphoblastic leukemia (ALL).
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CAR Construction :
Fig.1 Obinutuzumab binding to puried CD20. Size exclusion chromatography of CD20/ Obinutuzumab complex Top: Gel fltration chromatograms of CD20/ Obinutuzumab assembly and rituximab alone are shown in orange and red, respectively; Bottom: SDS-PAGE and stain free detection was used to analyze the gel fltration fractions. Agez, M., Mandon, E. D., Iwema, T., Gianotti, R., Limani, F., Herter, S., ... & Jawhari, A. (2019). Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab. Scientific reports, 9(1), 1-13. |
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CAR Construction :
Fig.2 CD20/antibodies binding by SPR. Sensorgram overlays showing the binding of anti-CD20 rituximab (blue), obinutuzumab (red) obinutuzumab wt (green) to purified CD20 captured by anti-His antibody. Agez, M., Mandon, E. D., Iwema, T., Gianotti, R., Limani, F., Herter, S., ... & Jawhari, A. (2019). Biochemical and biophysical characterization of purified native CD20 alone and in complex with rituximab and obinutuzumab. Scientific reports, 9(1), 1-13. |
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