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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 CD27 (1F5) h(28ζ), which is constructed for the engineering of T cells to target human CD27. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-CD27 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Thyroid cancer.
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CAR Construction :
Fig.1 ELISA binding to human CD27. Binding detected with an HRP-labeled goat anti-human IgG (Fc-specific) antibody. Vitale, L. A., He, L. Z., Thomas, L. J., Wasiuk, A., O’Neill, T., Widger, J., ... & Keler, T. (2020). Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy. Cancer Immunology, Immunotherapy, 69(10), 2125-2137. |
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CAR Construction :
Fig.2 SPR analysis of hCD27 mAb. His-tagged hCD27 ligand was immobilised onto the SPR chip at 20 response units (RU). To allow saturation of hCD27 binding sites, the indicated mAb were flowed over the immobilised hCD27 for 300 s. A 1:1 binding fitting was applied Heckel, F., Turaj, A. H., Fisher, H., Chan, H. T., Marshall, M. J., Dadas, O., ... & Lim, S. H. (2022). Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering. Communications biology, 5(1), 1-15. |
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