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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 PMEL (17A9) h(28ζ), which is constructed for the engineering of T cells to target human PMEL. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-PMEL antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Melanoma.
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CAR Construction :
Fig.1 Localization of antibody binding sites on PMEL17. Amino acid residues 25-125, 24 -104, 25- 85, 25- 65, and 25- 45 from the PMEL717 N-terminal domain (NTD) were fused to the gD epitope at the N terminus and GPI anchor at the C terminus. Chen, Y., Chalouni, C., Tan, C., Clark, R., Venook, R., Ohri, R., ... & Polakis, P. (2012). The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma. Journal of Biological Chemistry, 287(29), 24082-24091. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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