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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 VEGFR2 (Ramucirumab) h(28ζ), which is constructed for the engineering of T cells to target human VEGFR2. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-VEGFR2 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Melanoma.
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CAR Construction :
Fig.1 Competitive ELISA was carried out to examine dose-dependent inhibition of VEGF-A binding to VEGFR2 by hAb. A value of 100% was attributed to the binding of 4 nM VEGF-A to immobilized VEGFR2 in the absence of competitors. n = 4. |
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CAR Construction :
Fig.2 Determination of the binding activity of anti-VEGFR2 Ab to HUVECs by flow cytometry analysis. |
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CAR Construction :
Fig.3 Capillary structure formation assays were carried out using Matrigel-coated μ-Slides. |
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CAR Construction :
Fig.4 The Ab-dependent cellular cytotoxicity assay |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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