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BRCA1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Diseases associated with BRCA1 include Breast-Ovarian Cancer, Familial, 1 and Pancreatic Cancer 4. Among its related pathways are DNA Damage and DNA damage_Role of Brca1 and Brca2 in DNA repair.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ0049 Anti-BRCA1 (CA1-1) h(41BB-CD3ζ) CAR, pCDCAR1 Human CA1-1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0050 Anti-BRCA1 (CA1-2) h(41BB-CD3ζ) CAR, pCDCAR1 Human CA1-2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3473 Anti-BRCA1 (CA1-1) h(CD28-CD3ζ) CAR, pCDCAR1 Human CA1-1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ3474 Anti-BRCA1 (CA1-2) h(CD28-CD3ζ) CAR, pCDCAR1 Human CA1-2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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