Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Associated Disease
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| CAT | Product Name | Target Species | TCR Clone | Host Species | Epitope | Allele | Vector Type | Inquiry & Datasheet |
| TCR-L112 | Human anti-TERT (VYGFVRACL) T Cell Receptor, pGMT7 | Human | Human | VYGFVRACL | HLA-A*0201 | retroviral vector | ||
| TCR-L113 | Human anti-TERT (VYGFVRACL) T Cell Receptor[Cysteine-modified], pGMT7 | Human | Human | VYGFVRACL | HLA-A*2402 | retroviral vector | ||
| TCR-L111Z | Human anti-telomerase catalytic subunit protein (aa461-469) T cell receptor, pCDTCR1 | Human | Human | VYGFVRACL | HLA-A*0201 | Lentiviral | ||
| TCR-L112Z | Human anti-telomerase catalytic subunit protein (aa461-469) T cell receptor (Cysteine-modified), pCDTCR1 | Human | Human | VYGFVRACL | HLA-A*2402 | Lentiviral |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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