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TSLPR (Thymic stromal lymphopoietin protein receptor) is known as the cytokine receptor-like 2, CRL2 and IL-XR, which belongs to the type I cytokine receptor family. It is expressed mainly in myeloid cells, dendritic cells and activated monocytes. Also, TSLPR is weekly expressed in T cells. TSLPR is associated with acute lymphobiastic leukemia (ALL). Combined with the interleukin 7receptor (IL7R), TSLPR activate the pathways of STAT3, STAT5 and JAK2, which is regulated the processes of proliferation and development of the hematopoietic system.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-MZ094 | Anti-TSLPR (XHM549) h(CD8-41BB-CD3ζ) CAR, pCDCAR1 | Human | XHM549 | Mouse | scFv-CD8-41BB-CD3ζ | Lentiviral | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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