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TS-IL15 SA Anti-CEA (XW-263) 28BBζ CAR (XS-0822-YF10471)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human CEA chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • CEA
  • Targeting Diseases
  • Lung Cancer; Colorectal Cancer; Gastric Cancer; Breast Cancer; Pancreatic Cancer; Peritoneal Carcinomatosis; Gastrointestinal Cancers; Peritoneal Metastatic Colorectal Cancer
  • Generation
  • Third-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ

Target

  • Clone
  • XW-263
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • CEA cell adhesion molecule 5
  • Synonyms
  • CD66e, CEA
  • Introduction
  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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