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TS-IL15 SA Anti-EphA2 (XW-362) 28ζ CAR (XS-0822-YF9763)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Mouse EphA2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-CD28-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • EphA2
  • Targeting Diseases
  • Glioma
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-CD28-CD3ζ

Target

  • Clone
  • XW-362
  • Host
  • Mouse
  • Target Species
  • Mouse
  • Gene Name
  • EPH receptor A2
  • Synonyms
  • EphA2;EPHA2; EPH receptor A2; ECK; CTPA; ARCC2; CTPP1; CTRCT6;
  • Introduction
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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