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TS-NKG2DL Anti-hCD3 and Anti-CD33 (Lintuzumab) BBζ CAR (XS-0722-YF443)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human CD33 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • CD33
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Acute myeloid leukemia (AML)
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-NKG2DL Anti-hCD3 and (OKT3 scFv-NKG2D ECD)-EF1a-scFv-41BB-CD3ζ

Target

  • Clone
  • Lintuzumab
  • Host
  • Humanized
  • Target Species
  • Human
  • Gene Name
  • CD33
  • Synonyms
  • CD33;CD33; CD33 Molecule; CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67;
  • Introduction
  • Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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