Anti-BLNK aptamer SELEX Service(Cat#: CTApt-1752)
This is an aptamer development services to screening aptamers binds to the BLNK with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
BLNK |
| Alternative Names |
B Cell Linker; B-Cell Adapter Containing A SH2 Domain Protein; SLP-65; SLP65; BASH; Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD; Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa; B-Cell Adapter Containing A Src Homology 2 Domain Protein; B Cell Adaptor Containing SH2 Domain; Cytoplasmic Adapter Protein; B-Cell Linker Protein; B-Cell Activation; BLNK-S; Bca; AGM4; LY5; BLNK; Ly57 |
| Gene ID |
29760 |
| UniProt ID |
Q8WV28 |
| Target Overview |
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
