Pancreatic Cancer related Tumor Profiling Service

Tumor profiling in pancreatic cancer shows great significance in helping identify key molecular alterations, guide targeted therapies, and predict treatment responses and resistance. With our advanced platform of Tumor Profiling to Guide Targeted Cancer Therapy, Creative Biolabs has developed an unparalleled platform for tumor profiling in pancreatic cancer to facilitate your oncology research. To fulfill every need of our consumers, our professional scientists are ready to start working on your project!

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The Anatomy Schematic of Man with Pancreatic Cancer. (Creative Biolabs Authorized)

Background

Pancreatic cancer is a common worldwide cancer with a high lethal rate. The factors that contribute to its high fatality rate include the high genetic and epigenetic heterogeneity, therapeutic limitations, high metastatic propensity, and metabolic reprogramming of cancer cells. A comprehensive pancreatic tumor profiling could help intervene in tumor development, progression, and drug resistance.

Fig.1 The Characteristics of Pancreatic Tumor.

Fig.1 The Characteristics of Pancreatic Cancer.¹

Advanced Multi-Tumor Profiling System

Looking to unlock deeper insights into tumor heterogeneity? Creative Biolabs stands at the forefront of cancer research with our sophisticated tumor profiling solutions. Drawing upon cutting-edge platforms, we've successfully characterized diverse tumor populations across 10 major cancer types - from pancreatic cancer to non-small cell lung cancer and colorectal cancer. What sets us apart isn't just our advanced biomarker panels; it's our passionate team of scientists who work hand-in-hand with pharmaceutical companies and research institutions to accelerate drug development. While others might offer standard analytics, we pride ourselves on delivering actionable insights that drive your oncology programs forward. Ready to elevate your cancer research? Let's explore how our tumor profiling expertise can unlock new possibilities for your projects.

Pancreatic Cancer
Breast Cancer
Non-Small Cell Lung Cancer (NSCLC)
Colorectal Cancer
Melanoma Cancer
Brain Cancer
Ovarian Cancer
Endometrial Cancer
Thyroid Cancer
Head and Neck Cancer

Well-studied Biomarkers
Technologies	Genetic	Chromosomal	Transcriptional	Proteomic
Pancreatic Cancer
NGS FISH PCR IHC Microarray	Gene Variations KRAS TP53 SMAD4 CDKN2A RREB1 KDM6A RAC1 ARMET BRAF TGFBR2 ACVR1B MAP3K21 RAS ARMET RNF43	Chr 1~22 and Chr X, insertions, deletions, duplications, inversions and translocations	MicroRNAs, Long noncoding RNAs, DNA methylation	CA 19-9
Breast Cancer
NGS ISH PCR IHC Microarray	BRAF TP53 EGFR BRCA1/2 KRAS ERBB2/4 CDH1 MET CDK12 PTEN FGFR1/2/3 HRAS CHEK1/2 PIK3CA ATM	MET PTEN	HER2 ER PR	PD-L1 22C3 Pan-TRK
Non-Small Cell Lung Cancer (NSCLC)
NGS FISH PCR IHC Microarray FC IF	STK11 AKT1 EGFR BRAF KRAS ERBB2/4 TP53 MET FGFR1/2/3 CCND1 PTEN HRAS RB1 PIKЗCA ATM	ALK MET PTEN RET	VEGFA	PD-L1 HER2 Pan-TRK
Colorectal Cancer
NGS FISH IHC FC LC-MS	ALK AKT1 EGFR BRAF KRAS ERBB2/4 TP53 MET FGFR1/2/3 NOTCH1 PTEN ROS1 RB1 PIK3CA ATM	ALK MET PTEN RET ROS1	PD-L1	PD-L1 HER2 Pan-TRK
Melanoma Cancer
NGS FISH PCR IHC Microarray FC	AKT1 EGFR BRAF ERBB2/4 FGFR1/2/3 MET PDFFRA NRAS KIT CDK4	PTEN	MITF	PD-L1 Pan-TRK
Brain Cancer
NGS ISH PCR IHC Microarray	EGFR TP53 IDH1 EPHB2 APC MYC MLHI BAP1 SMAD4 COL4A1 ERBB2 HRAS AKT1 CDKN2B EPCAM	CDKN2A(p16) deletion EGFR amplification MET amplification CDKN2A (p16) deletion	ALK RAF1 BRAF ROS1 EGFR FGFR1	GFAP S100B
Ovarian Cancer
NGS FISH PCR IHC Microarray RT-PCR ELISA Whole Transcriptome Sequencing DNA Methylation	CTNNB1 PRKN TP53 PIKЗCA OPCML AKTI CDH1 ERBB2 RRAS2 PARK2 BRCA1/2 STK11 CDKN2B EPCAM		hyper- and hypo-methylation: OPCML DCR1 RASSF1A BRCA1 histone modification and miRNAs: Sirtuin-1 TGF	Cytokines/Chemokines: MFAP2 SEMG2 DLK1 Pro-apoptotic Proteins: NTNG1 CA-125 ILs XCL1 Angiogenic factors: CXCL7 VEGF EGFR ErbB2
Endometrial Cancer
NGS FISH PCR IHC Microarray FC IF RT-PCR ELISA	BRAF PIKЗCA APC BRCA1/2 SMAD4 HRAS TP53 CDH1 EGFR EPCAM KIT PTEN ESR1 MSH2/6 NRAS PDGFRA SMO SMARCA4 ATM FGFR1/2/3	MET PTEN	PD-L1	HER2 PDL1
Thyroid Cancer
NGS FISH PCR IHC Microarray	TP53 KRAS ERBB2/4 ALK ATM BRAF CDKN2A RET PIK3CA SMO CDKN2A PTEN SMAD4 HRAS CTNNB1	MET RET	PD-L1	Pan-TRK PD-L1
Head and Neck Cancer
NGS FISH PCR IHC Microarray IF ELISA	PTEN TP53 PTEN KRAS EGFR CTNNB1 BRAF PIK3CA ERBB2 FGFR1/2/3 CDKN2A NOTCH1 AKT1 RB1 ATM	MET PTEN RET	PD-L1	Pan-TRK PD-L1

Tumor Profiling in Pancreatic Cancer Is Used for

Personalized Cancer Treatment

Creative Biolabs provides comprehensive tumor profiling services to guide personalized cancer treatment, utilizing genomic, transcriptomic, and proteomic analyses. These services help identify actionable biomarkers and understand tumor heterogeneity to optimize therapeutic strategies.
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Diagnostic Tool

Our tumor profiling services serve as a powerful diagnostic tool, combining genomic, transcriptomic, and proteomic analyses to enhance cancer diagnosis and treatment planning by identifying key biomarkers and molecular alterations.
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Biomarker Discovery

Creative Biolabs specializes in tumor profiling for biomarker discovery, employing advanced genomic, transcriptomic, and proteomic techniques to identify novel biomarkers, accelerating cancer research, and facilitating the development of targeted therapies.
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Prognostic Assessment

Our tumor profiling services also support prognostic assessments, helping to predict disease outcomes by analyzing key biomarkers and molecular signatures, enabling personalized treatment strategies and informed clinical decision-making.
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Workflow for Pancreatic Tumor Profiling

1. Sample Processing

Fresh/FFPE tissue or liquid biopsy
Quality control and preservation
Sample validation

2. Multi-omics Analysis

Genomic profiling (WES/targeted sequencing)
RNA sequencing
Proteomic analysis
Metabolomic profiling

3. Data Integration

Bioinformatics pipeline
Pathway analysis
Target identification
Clinical relevance assessment

4. Deliverables

Comprehensive report
Data visualization
Therapeutic implications
Expert consultation

If you have any specific requirements for the whole profiling process, please do not hesitate to get in touch with us and our professional experts can tailor the tumor profiling services according to your needs.

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Why Choose Us?

Creative Biolabs' comprehensive tumor profiling with expert technologies and analysis. (Creative Biolabs Original)

Creative Biolabs offers high-quality services to support tumor profiling research. If you are interested in our services, contact us directly, and our team will give you an in-time reply.

References

Wang, Shun, et al. "The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives." Signal transduction and targeted therapy 6.1 (2021): 249. Distributed under Open Access license CC BY 4.0, without modification.

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