Intracellular Antibody
In molecular biology, there are a lot of intracellular proteins that are key regulators of various biological and pathophysiological processes and can serve as therapeutic targets. An intracellular antibody is an antibody that works within the cell to bind to an intracellular protein and achieve the therapeutic function. As the characterizations of large size, complex structure, and incompatibility with the intracellular environment make the intracellular antibody discovery really difficult. Creative Biolabs is now offering proprietary platforms that can promote our clients’ intracellular antibody discovery and development.
Super™ Transbody Development
Transbodies (also known as cell-permeable antibodies) are antibodies or antibody fragments that can penetrate the cell membrane and be internalized into the target cells. Compared with intrabodies, the conformational folding and the formation of disulfide bond for transbodies can happen before they are being translocated into the target cells and the no need for recombinant DNA technology avoids the permanent genetic changes in the target cells. Creative Biolabs is proud to establish an advanced Super™ transbody development platform to develop multiple formats of transbodies derived from various animal species. Moreover, a series of novel customized characteristics can be endowed through further engineering processes.
Super™ Intrabody Development
Intrabodies represent multiple formats of novel antibodies that have been developed and engineered for recognizing specific targets present in various organelles. With properly design and in frame fusion with intracellular trafficking/localization signals, specific intrabodies can be positioned on a series of subcellular locations. The discovery and development of properly intrabody is one of the most cutting-edge hotspots for either diagnostic or therapeutic applications. In term of our extensive experience in antibody development and engineering field, Creative Biolabs is able to provide unique Super™ intrabody development platform to generate high-quality intrabodies for our clients all over the world.
